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Invitation: Global Neurodisorders Researchers Gathering | Melbourne, Australia

We would like to announce the upcoming 25th World Congress on Neurology and Neurodisorders. On July 16-17, 2018, the conference has been scheduled in the beautiful City of Melbourne, Australia.

You are welcome to participate, and if you wish to you can submit an abstract for an oral presentation, poster or workshop. Abstracts of the conference will be published in the Conference Proceedings as well as in our journal: Journal of Neurology and Neuroscience.

We welcome your participation in this event along with your friends and we welcome your enquiries and suggestions. In the meantime, please check out our website for more details. Neurodisorders Congress 2018: https://neurodisorders.neurologyconference.com

In case you have any questions about the conference, give a call back at 1-650-889-4686 if convenient, or please feel free to contact the Program Manager Ms. Reshma Rani at: neurodisorders@neuroconferences.org  

We look forward to hearing from you soon.

With very best wishes,

Organizing Committee Members

John Baumann | Professor | University of Louisville, USA

Wai Kwong Tang | Professor | The Chinese University of Hong Kong, Hong Kong

Krupa Torne | HOD | Surya Children's Hospital Mumbai, India

Khamis AbdelKarim Elessi | Professor | Islamic University, Israel

Jose Antonio Gomez Rodriguez | Professor | UNAD Colombia, Columbia

Tran Thi Hanh | HOD | Can Tho Medical College, Vietnam

Ghulam Rasool Mashori | Professor | University of Medical and Health Sciences, Pakistan

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Promotion video: Neurodisorders Congress 2018

For more info: https://neurodisorders.neurologyconference.com/

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The mechanism of neuron death in motor neuron disease and frontotemporal dementia discovered.

Scientists have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.

Writing in Cell, the researchers from the University of Cambridge and University of Toronto also identify potential therapeutic targets for these currently incurable diseases.

In research funded by Wellcome, scientists used human cells that resembled neurons and neurons from frogs to investigate how the change in FUS from liquid droplets to small gels process is regulated and what makes it go awry. They found that this reversible process was tightly controlled by enzymes which chemically alter FUS making it able or unable to form droplets and gels. In frontotemporal dementia, the abnormal gelling was found to be caused by defects in the chemical modification of FUS. In motor neuron disease, it was caused by mutations in the FUS protein itself which meant it was no longer able to change form.

This research provides new ideas and tools to find ways to prevent or reverse the abnormal gelling of FUS as a treatment for these devastating diseases. Potential therapeutic targets identified by the researchers are the enzymes that regulate the chemical modification of FUS and the molecular chaperones that facilitate FUS proteins to change its form. These treatments would need to allow FUS to continue moving between safe reversible states (liquid droplets and reversible gels) but prevent FUS from dropping into the dense, irreversible gel states that cause disease.

Submit Your Abstract ...

The nervous system is vulnerable to the effects of certain chemicals and physical conditions found in the work environment. The activities of an occupational neurologist focus on the evaluation of patients with neurological disorders caused by occupational or environmental conditions. When one is making a differential diagnosis in patients with neurological disorders, the possibility of toxic exposure or encounters with physical factors in the workplace must not be overlooked. Central to an accurate clinical diagnosis is the patient's history. A diagnosis of an occupational or environmental neurological problem requires a careful assessment of the clinical abnormalities and confirmation of these disabilities by objective tests such as nerve conduction velocity, evoked potentials, electroencephalogram, neuropsychological batteries, or nerve biopsy. On the basis of information about hazards in the workplace, safety standards and environmental and biological monitoring can be implemented in the workplace to reduce the risks of undue injury. Clinical manifestations of headache, memory disturbance, and peripheral neuropathy are commonly encountered presentations of the effects of occupational hazards. Physicians in everyday clinical practice must be aware of the signs and symptoms associated with exposure to possible neurotoxins and work methods. Occupational and environmental circumstances must be explored when evaluating patients with neurologic disorders.